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Issue 10, 2012
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Harvesting 18F-fluoride ions in watervia direct 18F–19F isotopic exchange: radiofluorination of zwitterionic aryltrifluoroborates and in vivo stability studies

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Abstract

In this report, we show that [18F]-zwitterionic aryltrifluoroborates with ortho-phosphonium groups are: (i) easily accessible via direct 18F–19F isotopic exchange reactions in aqueous solutions; and (ii) efficiently stabilized in vivo against fluoride ion dissociation.

Graphical abstract: Harvesting 18F-fluoride ions in water via direct 18F–19F isotopic exchange: radiofluorination of zwitterionic aryltrifluoroborates and in vivo stability studies

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Publication details

The article was received on 27 Apr 2012, accepted on 14 Aug 2012 and first published on 05 Sep 2012


Article type: Concise Article
DOI: 10.1039/C2MD20105D
Med. Chem. Commun., 2012,3, 1305-1308

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    Harvesting 18F-fluoride ions in water via direct 18F–19F isotopic exchange: radiofluorination of zwitterionic aryltrifluoroborates and in vivo stability studies

    Z. Li, K. Chansaenpak, S. Liu, C. R. Wade, P. S. Conti and F. P. Gabbaï, Med. Chem. Commun., 2012, 3, 1305
    DOI: 10.1039/C2MD20105D

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