Issue 7, 2012
From the journal:

MedChemComm

Chemical synthesis and biological study of 4β-carboxymethyl-epiafzelechin acid, an osteoprotective compound from the rhizomes of Drynaria fortunei†

Man Chun Law,ab   Ka Chun Wong,ab   Wai Yin Pang,ab   Man Sau Wong*ab  and  Tak Hang Chan*ab  

* Corresponding authors

a Department of Applied Biology and Chemical Technology and Laboratory of the Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong Polytechnic University, Hong Kong SAR, China
E-mail: man-sau.wong@polyu.edu.hk, tak.hong.chan@polyu.edu.hk

b State Key Laboratory in Chinese Medicine and Molecular Pharmacology, Shenzhen, China

Abstract

The chemically synthesized active osteoprotective component 12 of Drynaria fortunei (kunze) J. Sm showed potent proliferative activity on UMR-106 osteoblast-like cells and selectively activate ERE-dependent gene transcription mediated by ERα but not ERβ.

Graphical abstract: Chemical synthesis and biological study of 4β-carboxymethyl-epiafzelechin acid, an osteoprotective compound from the rhizomes of Drynaria fortunei

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Article information

DOI
https://doi.org/10.1039/C2MD20082A
Article type
Concise Article
Submitted
29 Mar 2012
Accepted
22 May 2012
First published
25 May 2012

Med. Chem. Commun., 2012,3, 801-806

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Chemical synthesis and biological study of 4β-carboxymethyl-epiafzelechin acid, an osteoprotective compound from the rhizomes of Drynaria fortunei

M. C. Law, K. C. Wong, W. Y. Pang, M. S. Wong and T. H. Chan, Med. Chem. Commun., 2012, 3, 801 DOI: 10.1039/C2MD20082A

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