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Issue 5, 2012
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The synthesis and receptor binding affinities of DDD-016, a novel, potential, atypical antipsychotic

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Abstract

A new pentacyclic compound, DDD-016 (10d) was designed and synthesized as a potential antipsychotic and screened for binding affinity in a broad panel of over 80 CNS and other receptors, monoamine transporters, and ion channels. The resulting receptor binding profile of DDD-016 is consistent with that of an improved atypical antipsychotic candidate.

Graphical abstract: The synthesis and receptor binding affinities of DDD-016, a novel, potential, atypical antipsychotic

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Article information


Submitted
21 Dec 2011
Accepted
06 Mar 2012
First published
07 Mar 2012

Med. Chem. Commun., 2012,3, 580-583
Article type
Concise Article

The synthesis and receptor binding affinities of DDD-016, a novel, potential, atypical antipsychotic

A. Bandyopadhyaya, D. R. Rajagopalan, N. P. Rath, A. Herrold, R. Rajagopalan, T. C. Napier, C. E. Tedford and P. Rajagopalan, Med. Chem. Commun., 2012, 3, 580
DOI: 10.1039/C2MD00311B

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