Issue 1, 2012
From the journal:

MedChemComm

Synthesis of chiral α-amino acid-derived 1H-1,2,4-triazoles and 1,2,4-triazines†

Ebrahim H. Ghazvini Zadeh,a   Bahaa El-Dien M. El-Gendy,ab   Alex G. Popa  and  Alan R. Katritzky*ac  

* Corresponding authors

a Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL
E-mail: katritzky@chem.ufl.edu.Address
Fax: +352-392-919
Tel: +352-392-0554

b Department of Chemistry, Faculty of Science, Benha University, Benha, Egypt

c Department of Chemistry, King Abdulaziz University, Jeddah, Saudi Arabia

Abstract

Enantiopure N-(Cbz, Fmoc, Boc, or Ac)-1H-1,2,4-triazole- (8a–p, and 8f′) and previously unknown N-Cbz-1,2,4-triazine-derived α-amino acids (11a–d, 11d′, 13a,b, and 13a′) were synthesized using microwave irradiation. Reaction conditions led unexpectedly to simultaneous cyclization, deprotection and acetylation of N-Boc-aminoacylamidrazones 7m,n to afford N-acetyl-1H-1,2,4-triazoles 8o,p.

Graphical abstract: Synthesis of chiral α-amino acid-derived 1H-1,2,4-triazoles and 1,2,4-triazines

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Article information

DOI
https://doi.org/10.1039/C1MD00177A
Article type
Concise Article
Submitted
08 Jul 2011
Accepted
08 Oct 2011
First published
14 Nov 2011

Med. Chem. Commun., 2012,3, 52-55

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Synthesis of chiral α-amino acid-derived 1H-1,2,4-triazoles and 1,2,4-triazines

E. H. Ghazvini Zadeh, B. E. M. El-Gendy, A. G. Pop and A. R. Katritzky, Med. Chem. Commun., 2012, 3, 52 DOI: 10.1039/C1MD00177A

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