Issue 11, 2012
From the journal:

Molecular BioSystems

Aminoglycoside antibiotics bind to the influenza A virus RNA promoter†

Henna Kim,a   Mi-Kyung Lee,a   Junsang Ko,a   Chin-Ju Park,b   Meehyein Kim,c   Yujeong Jeong,a   Sungwoo Hong,a   Gabriele Varanid  and  Byong-Seok Choi*a  

* Corresponding authors

a Department of Chemistry, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Korea
E-mail: byongseok.choi@kaist.ac.kr

b GIST, 123 Cheomdan-Gwagiro, Buk-gu, Gwangju 500-712, Korea

c KRICT, P.O.Box 107, Sinseongno 19, Yuseong-gu, Daejeon 305-660, Korea

d Department of Chemistry, University of Washington, Seattle, WA 98195, USA

Abstract

Aminoglycosides bind to the influenza A virus promoter (vRNA) at submicromolar concentration. The complex structure between the vRNA and neomycin illustrates that binding of neomycin causes a conformational change which would affect further transcription processes. Thus, aminoglycosides represent lead compounds for the discovery of antiviral therapeutics against influenza A virus.

Graphical abstract: Aminoglycoside antibiotics bind to the influenza A virus RNA promoter

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Article information

DOI
https://doi.org/10.1039/C2MB25333J
Article type
Communication
Submitted
14 Aug 2012
Accepted
07 Sep 2012
First published
12 Sep 2012

Mol. BioSyst., 2012,8, 2857-2859

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Aminoglycoside antibiotics bind to the influenza A virus RNA promoter

H. Kim, M. Lee, J. Ko, C. Park, M. Kim, Y. Jeong, S. Hong, G. Varani and B. Choi, Mol. BioSyst., 2012, 8, 2857 DOI: 10.1039/C2MB25333J

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