Modulation of gap junction channels and hemichannels by growth factors
Abstract
Gap junction hemichannels and cell–cell channels have roles in coordinating numerous cellular processes, due to their permeability to extra and intracellular signaling molecules. Another mechanism of cellular coordination is provided by a vast array of growth factors that interact with relatively selective cell membrane receptors. These receptors can affect cellular transduction pathways, including alteration of intracellular concentration of free Ca2+ and free radicals and