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Issue 35, 2012
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A pluronic F127 coating strategy to produce stable up-conversion NaYF4:Yb,Er(Tm) nanoparticles in culture media for bioimaging

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Abstract

Up-conversion nanoparticles (UCNPs) have exhibited great potential in biological imaging and labeling. The further development of the correlated techniques strongly depends on the stability of UCNPs in buffers and biological growth media. In this paper, Pluronic F127, a nonionic triblock copolymer of poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (PEO-b-PPO-b-PEO), is applied to coat the originally hydrophobic NaYF4:Yb,Er(Tm) UCNPs, leading to an oil-to-water phase transfer. After the phase transfer, F127-coated UCNPs are well dispersed in water with more than 43% UC luminescence preserved. Because of the nonionic nature of F127, the F127-coated UCNPs are quite stable in culture media, and exhibit excellent biocompatibility and low toxicity. The biocompatible decoration using F127 is facile and repeatable, thus facilitating the biological applications of UCNPs. As an example, the bioimaging of caenorhabditis elegans is demonstrated.

Graphical abstract: A pluronic F127 coating strategy to produce stable up-conversion NaYF4:Yb,Er(Tm) nanoparticles in culture media for bioimaging

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Publication details

The article was received on 06 Jun 2012, accepted on 19 Jul 2012 and first published on 02 Aug 2012


Article type: Paper
DOI: 10.1039/C2JM33626J
Citation: J. Mater. Chem., 2012,22, 18596-18602
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    A pluronic F127 coating strategy to produce stable up-conversion NaYF4:Yb,Er(Tm) nanoparticles in culture media for bioimaging

    Z. Wu, C. Guo, S. Liang, H. Zhang, L. Wang, H. Sun and B. Yang, J. Mater. Chem., 2012, 22, 18596
    DOI: 10.1039/C2JM33626J

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