Jump to main content
Jump to site search

Issue 26, 2012
Previous Article Next Article

ZnO@silica core–shell nanoparticles with remarkable luminescence and stability in cell imaging

Author affiliations

Abstract

Monodispersed silica-coated ZnO nanoparticles were successfully synthesized and modified with hydrophilic amino groups on the surfaces. The emission colour of the as-prepared ZnO nanoparticles could be tuned by adjusting the reactant ratio and the reaction time. The resulting particles were stable in water, phosphate buffer saline and cell culture medium. Their aqueous solutions had high quantum yields of 53.8%, 48.7% and 33.5%, corresponding to blue, green and yellow emitting ZnO@silica nanoparticles respectively. And the cytotoxicity (24 hours LC50 for Hela cells) of these three samples was 315, 374 and 241 μg mL−1 respectively. The cytotoxicity data and the cellular uptake kinetics experiments confirmed the safety of all these ZnO@silica nanoparticles under visible light, while under UV light of 365 nm the yellow emitting ZnO@silica was fatal to Hela cells because it released plenty of reactive oxygen species.

Graphical abstract: ZnO@silica core–shell nanoparticles with remarkable luminescence and stability in cell imaging

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 Feb 2012, accepted on 08 May 2012 and first published on 09 May 2012


Article type: Paper
DOI: 10.1039/C2JM30855J
Citation: J. Mater. Chem., 2012,22, 13159-13165
  •   Request permissions

    ZnO@silica core–shell nanoparticles with remarkable luminescence and stability in cell imaging

    H. Zhang, H. Xiong, Q. Ren, Y. Xia and J. Kong, J. Mater. Chem., 2012, 22, 13159
    DOI: 10.1039/C2JM30855J

Search articles by author

Spotlight

Advertisements