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Issue 18, 2012
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Light-triggered NO release from a nanofibrous non-woven

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Abstract

Light-controlled NO delivery systems promise new applications in phototherapies. For this purpose, a ruthenium nitrosyl complex [(2)Ru(NO)(Cl)] with the novel ligand N,N′-(1,2-phenylene)bis(1-methyl-1H-imidazole-2-carboxamide) (2) has been synthesised and characterised in detail. The photoactive {Ru–NO}6 nitrosyl released NO in DMSO upon exposure to low-intensity UV-A light (λ = 366 nm). In order to create an applicable system the water-insoluble [(2)Ru(NO)(Cl)] was embedded into poly(L-lactide-co-D/L-lactide) nanofibrous non-wovens by electrospinning. Exposure of a 25 wt% non-woven of [(2)Ru(NO)(Cl)] to UV-A light resulted in a continuous release of NO into an aqueous solution. The cytoxicity of the non-woven against 3T3 mouse fibroblasts was very low.

Graphical abstract: Light-triggered NO release from a nanofibrous non-woven

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Article information


Submitted
24 Oct 2011
Accepted
06 Feb 2012
First published
08 Mar 2012

J. Mater. Chem., 2012,22, 8785-8792
Article type
Paper

Light-triggered NO release from a nanofibrous non-woven

C. Bohlender, M. Wolfram, H. Goerls, W. Imhof, R. Menzel, A. Baumgaertel, U. S. Schubert, U. Mueller, M. Frigge, M. Schnabelrauch, R. Wyrwa and A. Schiller, J. Mater. Chem., 2012, 22, 8785
DOI: 10.1039/C2JM15410B

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