Issue 8, 2012

Modified silicon nanowires: a fluorescent nitric oxide biosensor with enhanced selectivity and stability

Abstract

A fluorescence sensor for nitric oxide (NO) was realized by covalently immobilizing reduced fluoresceinamine molecules onto the surface of silicon nanowires (SiNWs). The fluorescence intensity of the sensor can be greatly enhanced by NO. The sensor exhibits excellent selectivity for NO against other reactive species. Facile synthesis, nontoxicity, rapid response and use in a 100% aqueous solution endows the present sensor with suitability for biosystems. As an application, the sensor was used to detect NO released from liver extract, and exhibited high sensitivity and selectivity as well as rapid response. The fluorescence image from a single SiNW-based sensor showed a fine spatial resolution. The present sensor paves a way to detect NO at specific location in a single cell by inserting a single SiNW-based sensor into the cell.

Graphical abstract: Modified silicon nanowires: a fluorescent nitric oxide biosensor with enhanced selectivity and stability

Supplementary files

Additions and corrections

Article information

Article type
Paper
Submitted
12 Oct 2011
Accepted
14 Nov 2011
First published
16 Jan 2012

J. Mater. Chem., 2012,22, 3348-3353

Modified silicon nanowires: a fluorescent nitric oxide biosensor with enhanced selectivity and stability

R. Miao, L. Mu, H. Zhang, H. Xu, G. She, P. Wang and W. Shi, J. Mater. Chem., 2012, 22, 3348 DOI: 10.1039/C1JM15165G

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