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Issue 2, 2012
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Rapid screening of arsenic species in urine from exposed human by inductively coupled plasma mass spectrometry with germanium as internal standard

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Abstract

In the present work, internal standardization based on species-unspecific isotope dilution analysis technique is proposed in order to overcome the matrix effects and signal drift originated in the speciation of As in urine by HPLC-ICP-MS. To this end, 72Ge has been selected as a pseudo-isotope of As. The resulting mass flow chromatogram of the element allows the calculation of the corrected overall species concentrations without requiring any methodological calibration, providing high-throughput sample processing. The validation was carried out by analyzing a blank human urine fortified at three concentration levels and an unspiked human urine sample containing different species of arsenic. In all cases, recoveries ranging from 90 to 115% and RSD below 10% were attained with this approach. Furthermore, the proposed method provided results in excellent agreement with those obtained using standard additions and internal standard calibration, allowing a fast way to assess human exposure to arsenic species.

Graphical abstract: Rapid screening of arsenic species in urine from exposed human by inductively coupled plasma mass spectrometry with germanium as internal standard

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Publication details

The article was received on 28 Sep 2011, accepted on 01 Nov 2011 and first published on 08 Dec 2011


Article type: Technical Note
DOI: 10.1039/C1JA10289C
Citation: J. Anal. At. Spectrom., 2012,27, 354-358

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    Rapid screening of arsenic species in urine from exposed human by inductively coupled plasma mass spectrometry with germanium as internal standard

    A. Castillo, C. Boix, N. Fabregat, A. F. Roig-Navarro and J. A. Rodríguez-Castrillón, J. Anal. At. Spectrom., 2012, 27, 354
    DOI: 10.1039/C1JA10289C

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