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Issue 8, 2012
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Anastomosis of endothelial sprouts forms new vessels in a tissue analogue of angiogenesis

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Abstract

Here we describe a microfluidic device that accurately reproduces the dynamics of vascular anastomosis, the process by which vascular sprouts connect to achieve perfusion during angiogenesis. The micro-device features two parallel endothelial cell-lined vessel analogues separated by a 300 μm wide collagenous matrix into which the vessels can sprout and form perfused bridging connections. By accurately recapitulating anastomosis in vitro, the device will enable a new generation of studies of the mechanisms of angiogenesis and provide a novel and practical platform for drug screening.

Graphical abstract: Anastomosis of endothelial sprouts forms new vessels in a tissue analogue of angiogenesis

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Publication details

The article was received on 20 Dec 2011, accepted on 09 May 2012 and first published on 17 May 2012


Article type: Paper
DOI: 10.1039/C2IB20061A
Citation: Integr. Biol., 2012,4, 857-862

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