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Issue 4, 2012
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Catalyst-free and highly selective electrophilic mono-fluorination of acetoacetamides: facile and efficient preparation of 2-fluoroacetoacetamides in PEG-400

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Abstract

Series of α-mono-fluorinated acetoacetamides were synthesized under mild condition with industrialized Selectfluor as the F+ source in PEG-400. The approach avoided the use of base or metal catalyst, and most of cases proceeded in nearly quantitative conversions regardless of the electronic nature of the diversity substituent.

Graphical abstract: Catalyst-free and highly selective electrophilic mono-fluorination of acetoacetamides: facile and efficient preparation of 2-fluoroacetoacetamides in PEG-400

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Article information


Submitted
24 Dec 2011
Accepted
13 Feb 2012
First published
02 Mar 2012

Green Chem., 2012,14, 1159-1162
Article type
Paper

Catalyst-free and highly selective electrophilic mono-fluorination of acetoacetamides: facile and efficient preparation of 2-fluoroacetoacetamides in PEG-400

J. Bi, Z. Zhang, Q. Liu and G. Zhang, Green Chem., 2012, 14, 1159
DOI: 10.1039/C2GC16661E

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