Pressure-accelerated copper-free cycloaddition of azide and alkyne groups pre-organized in the crystalline state at room temperature

Abstract

We have designed a supramolecular system to pre-organize the azide and alkyne functional groups via electrostatic and arene–perfluoroarene interactions. After pre-organization, high pressure was applied to accelerate the copper-free cycloaddition of the azide and alkyne groups in the crystalline state.