Issue 10, 2012
From the journal:

Green Chemistry

Copper(ii) catalysis provides cyclohexanone-derived propargylamines free of solvent or excess starting materials: sole by-product is water†

Conor J. Piercea  and  Catharine H. Larsen*a  

* Corresponding authors

a Department of Chemistry, University of California Riverside, 501 W Big Springs Rd, Riverside, CA 92521, USA
E-mail: catharine.larsen@ucr.edu
Tel: (+1)-951-827-4964

Abstract

A high-yielding three-component reaction proceeds under mild, solvent-free conditions for access to a wide variety of fully-substituted propargylamines. Inexpensive copper(II) chloride catalyzes the coupling of equimolar amounts of amines, alkynes, and cyclohexanone such that the only by-product is one equivalent of water.

Graphical abstract: Copper(ii) catalysis provides cyclohexanone-derived propargylamines free of solvent or excess starting materials: sole by-product is water

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Article information

DOI
https://doi.org/10.1039/C2GC35713E
Article type
Communication
Submitted
10 May 2012
Accepted
26 Jun 2012
First published
18 Jul 2012

Green Chem., 2012,14, 2672-2676

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Copper(II) catalysis provides cyclohexanone-derived propargylamines free of solvent or excess starting materials: sole by-product is water

C. J. Pierce and C. H. Larsen, Green Chem., 2012, 14, 2672 DOI: 10.1039/C2GC35713E

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