Issue 7, 2012
From the journal:

Green Chemistry

Synthesis of C6-azolyl purine nucleosides via C–N coupling reaction of unprotected 6-chloropurine nucleosides and N-heterocycles under catalyst- and solvent-free conditions†

Gui-Rong Qu,*a   Hong-Liang Zhang,a   Hong-Ying Niu,b   Zai-Kun Xue,a   Xin-Xin Lva  and  Hai-Ming Guo*a  

* Corresponding authors

a College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, Xinxiang 453007, Henan, China
E-mail: quguir@sina.com, guohm518@hotmail.com
Fax: +86 373 3329276
Tel: +86 373 3329255

b School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang 453003, China

Abstract

C6-azolyl purine nucleoside products are prepared in high yields under solvent- and catalyst-free conditions via C–N coupling reaction of unprotected 6-chloropurine nucleosides and N-heterocycles, providing a unifying, simple and environmentally friendly complement to the available methods.

Graphical abstract: Synthesis of C6-azolyl purine nucleosides via C–N coupling reaction of unprotected 6-chloropurine nucleosides and N-heterocycles under catalyst- and solvent-free conditions

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Article information

DOI
https://doi.org/10.1039/C2GC35419E
Article type
Communication
Submitted
21 Mar 2012
Accepted
14 May 2012
First published
14 May 2012

Green Chem., 2012,14, 1877-1879

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Synthesis of C6-azolyl purine nucleosides via C–N coupling reaction of unprotected 6-chloropurine nucleosides and N-heterocycles under catalyst- and solvent-free conditions

G. Qu, H. Zhang, H. Niu, Z. Xue, X. Lv and H. Guo, Green Chem., 2012, 14, 1877 DOI: 10.1039/C2GC35419E

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