Issue 4, 2012
From the journal:

Green Chemistry

Racemic and diastereoselective construction of indole alkaloids under solvent- and catalyst-free microwave-assisted Pictet–Spengler condensation†

Mouhamad Jida,*a   Olivier-Mohamad Soueidan,b   Benoit Deprez,a   Guillaume Lacondea  and  Rebecca Deprez-Poulaina  

* Corresponding authors

a Biostructures and Drug Discovery, INSERM U761, Faculté de Pharmacie, Université Lille Nord de France, 3 rue du Pr Laguesse Lille F-59006, France
E-mail: mhmd_jida@yahoo.com
Fax: (+33) 640607000

b Université Lille Nord de France, USTL, ENSCL, Unité de Catalyse et de Chimie de Solide, CNRS UMR 8181, France

Abstract

An environment-friendly high-yielding method for the racemic and asymmetric diastereoselective preparation of indole alkaloids via Pictet–Spengler reaction is reported. The reaction proceeds with short reaction times under solvent-free and microwave-irradiation conditions.

Graphical abstract: Racemic and diastereoselective construction of indole alkaloids under solvent- and catalyst-free microwave-assisted Pictet–Spengler condensation

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Article information

DOI
https://doi.org/10.1039/C2GC16596A
Article type
Communication
Submitted
12 Dec 2011
Accepted
18 Jan 2012
First published
22 Feb 2012

Green Chem., 2012,14, 909-911

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Racemic and diastereoselective construction of indole alkaloids under solvent- and catalyst-free microwave-assisted Pictet–Spengler condensation

M. Jida, O. Soueidan, B. Deprez, G. Laconde and R. Deprez-Poulain, Green Chem., 2012, 14, 909 DOI: 10.1039/C2GC16596A

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