Jump to main content
Jump to site search

Issue 4, 2012
Previous Article Next Article

Ester as a blocking group for palladium-catalysed direct forced arylation at the unfavourable site of heteroaromatics: simple access to the less accessible regioisomers

Author affiliations

Abstract

The use of esters as blocking groups at the C2 position on a range of 3-substituted 5-membered ring heteroaromatics such as thiophenes or furans, allows control of the regioselectivity for the palladium-catalysed direct arylation at C5-H. This arylation can be followed by easy decarboxylation. This method allows sequential catalytic C5 arylation, decarboxylation and catalytic C2 arylation reactions.

Graphical abstract: Ester as a blocking group for palladium-catalysed direct forced arylation at the unfavourable site of heteroaromatics: simple access to the less accessible regioisomers

Back to tab navigation

Publication details

The article was received on 15 Nov 2011, accepted on 28 Jan 2012 and first published on 01 Mar 2012


Article type: Paper
DOI: 10.1039/C2GC16460D
Green Chem., 2012,14, 1111-1124

  •   Request permissions

    Ester as a blocking group for palladium-catalysed direct forced arylation at the unfavourable site of heteroaromatics: simple access to the less accessible regioisomers

    L. Chen, C. Bruneau, P. H. Dixneuf and H. Doucet, Green Chem., 2012, 14, 1111
    DOI: 10.1039/C2GC16460D

Search articles by author

Spotlight

Advertisements