Issue 2, 2012
From the journal:

Green Chemistry

l-Proline catalysed multicomponent synthesis of 3-amino alkylated indolesvia a Mannich-type reaction under solvent-free conditions†

Atul Kumar,*a   Maneesh Kumar Guptaa  and  Mukesh Kumara  

* Corresponding authors

a Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow, India
E-mail: dratulsax@gmail.com
Fax: 91-522-26234051
Tel: 91-522-2612411

Abstract

An efficient L-proline catalyzed one-pot synthesis of 3-amino-alkylated indoles has been developed via a three-component Mannich-type reaction viz.secondary amines, aldehyde and indoles under solvent-free conditions at room temperature. Several amino acids (acidic, basic and neutral) have been screened for the reaction but the best results were obtained with L-proline.

Graphical abstract: l-Proline catalysed multicomponent synthesis of 3-amino alkylated indolesvia a Mannich-type reaction under solvent-free conditions

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Article information

DOI
https://doi.org/10.1039/C1GC16297G
Article type
Communication
Submitted
18 Oct 2011
Accepted
19 Oct 2011
First published
16 Nov 2011

Green Chem., 2012,14, 290-295

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L-Proline catalysed multicomponent synthesis of 3-amino alkylated indolesvia a Mannich-type reaction under solvent-free conditions

A. Kumar, M. K. Gupta and M. Kumar, Green Chem., 2012, 14, 290 DOI: 10.1039/C1GC16297G

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