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Issue 7, 2012
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Hypoglycemic and antioxidant potential of coconut water in experimental diabetes

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Abstract

Coconut water is a natural nutritious beverage that contains several biologically active compounds. The present study aims to evaluate the hypoglycemic and antioxidant effects of mature coconut water (MCW) on alloxan-induced diabetes in experimental rats. The experimental animals were divided into four groups – normal control, normal rats treated with MCW, diabetic control and diabetic rats treated with MCW. The blood glucose, plasma insulin, hemoglobin, glycated hemoglobin, activities of the various antioxidant enzymes (catalase, superoxide dismutase, glutathione peroxidase and glutathione reductase) and lipid peroxidation markers (malondialdehyde, hydroperoxides and conjugated dienes) were evaluated in all the groups. The results indicate that the diabetic animals treated with MCW had decreased blood glucose levels and reduced oxidative stress induced by alloxan, which was evident from the increased activities of the antioxidant enzymes and the decreased levels of the lipid peroxidation products. The overall results indicate that MCW significantly attenuated hyperglycemia and oxidative stress in alloxan-induced diabetic rats, indicating the therapeutic potential of MCW.

Graphical abstract: Hypoglycemic and antioxidant potential of coconut water in experimental diabetes

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Article information


Submitted
16 Mar 2012
Accepted
23 Apr 2012
First published
25 Apr 2012

Food Funct., 2012,3, 753-757
Article type
Paper

Hypoglycemic and antioxidant potential of coconut water in experimental diabetes

P. P. Preetha, V. G. Devi and T. Rajamohan, Food Funct., 2012, 3, 753
DOI: 10.1039/C2FO30066D

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