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Issue 8, 2012
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Scopoletin attenuates allergy by inhibiting Th2 cytokines production in EL-4 T cells

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Abstract

Scopoletin is an antioxidant found in certain weedy plants. It exerts anti-inflammatory, anti-allergic, and anti-diabetic activities. It remains unknown whether scopoletin regulates T helper (Th) cells, including Th 1 and Th 2 cells. We found that scopoletin significantly inhibited phorbol myristate acetate (PMA)/ionomycin-induced interleukin-4 (IL-4), IL-5, and IL-10 production in EL-4 T cells. In addition, scopoletin significantly enhanced the inhibitory action of PMA/ionomycin on interferon-γ (IFN-γ) expression. In EL-4 T cells, PMA/ionomycin treatment markedly increased the expression of nuclear factor of activated T cells (NFAT) and GATA-3; in contrast, scopoletin significantly down-regulated expressions of these transcription factors. Furthermore, this downregulation depended on protein kinase C (PKC) attenuation. This leads us to suggest that the anti-allergic properties of scopoletin might be mediated by the downregulation of cytokine expression in Th 2 cells.

Graphical abstract: Scopoletin attenuates allergy by inhibiting Th2 cytokines production in EL-4 T cells

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Article information


Submitted
05 Mar 2012
Accepted
19 May 2012
First published
30 May 2012

Food Funct., 2012,3, 886-890
Article type
Paper

Scopoletin attenuates allergy by inhibiting Th2 cytokines production in EL-4 T cells

A. Cheng, Y. Cheng and T. Chang, Food Funct., 2012, 3, 886
DOI: 10.1039/C2FO30054K

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