Issue 18, 2012
From the journal:

Dalton Transactions

Gold nanoparticles functionalised with stable, fast water exchanging Gd3+ chelates as high relaxivity contrast agents for MRI†

M. F. Ferreira,a   B. Mousavi,b   P. M. Ferreira,a   C. I. O. Martins,c   L. Helm,*b   J. A. Martins*a  and  C. F. G. C. Geraldesc  

* Corresponding authors

a Centro de Química, Campus de Gualtar, Universidade do Minho, 4710-057 Braga, Portugal
E-mail: jmartins@quimica.uminho.pt
Fax: +351253604382
Tel: +351253604385

b Laboratoire de Chimie Inorganique et Bioinorganique, Ecole Polytechnique Féderale de Lausanne, EPFL-BCH CH-1015 Lausanne, Switzerland
E-mail: lothar.helm@epfl.ch
Fax: +41 (0)21 693 98 95
Tel: +41 (0)21 693 98 76

c Department of Life Sciences, Faculty of Science and Technology, and Center of Neurosciences and Cell Biology, University of Coimbra, P.O. Box 3046, 3001-401 Coimbra, Portugal
E-mail: geraldes@ci.uc.pt
Fax: +351239853607
Tel: +351239853608

Abstract

Gold nanoparticles functionalized with Gd3+ chelates displaying fast water exchange, superb pH stability and inertness towards transmetalation with Zn2+ have been prepared and characterized as a new high relaxivity (29 mM−1 s−1, 30 MHz, 25 °C) contrast agent potentially safe for in vivo MRI applications. The Lipari–Szabo treatment for internal rotation was used to evaluate the effect of linker flexibility on the relaxivity of the gold nanoparticles. The effect of fast water exchange on the relaxivity of gold nanoparticles functionalized with Gd3+ chelates is also addressed in this communication.

Graphical abstract: Gold nanoparticles functionalised with stable, fast water exchanging Gd3+ chelates as high relaxivity contrast agents for MRI

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2DT30388D
Article type
Communication
Submitted
18 Feb 2012
Accepted
13 Mar 2012
First published
13 Mar 2012

Dalton Trans., 2012,41, 5472-5475

Permissions

Request permissions

Gold nanoparticles functionalised with stable, fast water exchanging Gd3+ chelates as high relaxivity contrast agents for MRI

M. F. Ferreira, B. Mousavi, P. M. Ferreira, C. I. O. Martins, L. Helm, J. A. Martins and C. F. G. C. Geraldes, Dalton Trans., 2012, 41, 5472 DOI: 10.1039/C2DT30388D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements