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Issue 23, 2012
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Reactions and structural characterization of gold(iii) complexes with amino acids, peptides and proteins

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Abstract

The present review article highlights recent findings in the field of gold(III) complexes with amino acids, peptides and proteins. The first section of this article provides an overview of the gold(III) reactions with amino acids, such as glycine, alanine, histidine, cysteine and methionine. The second part of the review is mainly focused on the results achieved in the mechanistic studies of the reactions between gold(III) and different peptides and structural characterization of gold(III)–peptide complexes as the final products in these reactions. The last section of this article deals with the reactions of gold(III) complexes with proteins as primary targets for cytotoxic gold compounds. Systematic summaries of these results contribute to the future development of gold(III) complexes as potential antitumor agents and also have importance in relation to the severe toxicity of gold-based drugs.

Graphical abstract: Reactions and structural characterization of gold(iii) complexes with amino acids, peptides and proteins

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Publication details

The article was received on 23 Jan 2012, accepted on 16 Mar 2012 and first published on 19 Mar 2012


Article type: Perspective
DOI: 10.1039/C2DT30169E
Dalton Trans., 2012,41, 6887-6901

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    Reactions and structural characterization of gold(III) complexes with amino acids, peptides and proteins

    B. Đ. Glišić, U. Rychlewska and M. I. Djuran, Dalton Trans., 2012, 41, 6887
    DOI: 10.1039/C2DT30169E

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