Issue 21, 2012
From the journal:

Dalton Transactions

A novel conjugate of a cell-penetrating peptide and a ferrocenyl amino acid: a potential electrochemical sensor for living cells?

Jan Hoyer,ab   Andrea Hunold,c   Hans-Günther Schmalzc  and  Ines Neundorf*ad  

* Corresponding authors

a Translational Centre for Regenerative Medicine, Philipp-Rosenthal-Str. 55, Germany
E-mail: jhoyer@uni-leipzig.de

b Institute of Biochemistry, University of Leipzig, Brüderstr. 34, 04103 Leipzig, Germany

c Institute of Organic Chemistry, University of Cologne, Greinstr. 4, 50939 Cologne, Germany
E-mail: schmalz@uni-koeln.de
Fax: +49 (0) 221 470 3064

d Institute of Biochemistry, Department of Chemistry, University of Cologne, Zülpicher Str. 47, 50674 Cologne, Germany
E-mail: ines.neundorf@uni-koeln.de
Fax: +49 (0) 221 470 6431

Abstract

The conjugation of a ferrocenyl amino acid to the cell-penetrating peptide hCT(9–32) does not impair its ability to efficiently translocate into cells. Furthermore, the bioconjugate does not induce any cytotoxicity, thus presenting a potential electrochemical sensor suitable for the detection of living cells.

Graphical abstract: A novel conjugate of a cell-penetrating peptide and a ferrocenyl amino acid: a potential electrochemical sensor for living cells?

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Article information

DOI
https://doi.org/10.1039/C2DT12211A
Article type
Communication
Submitted
18 Nov 2011
Accepted
27 Feb 2012
First published
14 Mar 2012

Dalton Trans., 2012,41, 6396-6398

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A novel conjugate of a cell-penetrating peptide and a ferrocenyl amino acid: a potential electrochemical sensor for living cells?

J. Hoyer, A. Hunold, H. Schmalz and I. Neundorf, Dalton Trans., 2012, 41, 6396 DOI: 10.1039/C2DT12211A

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