Issue 3, 2012
From the journal:

Dalton Transactions

Substitution behaviour of novel dinuclear Pt(ii) complexes with bio-relevant nucleophiles†

Tanja Soldatović,a   Snežana Jovanović,b   Živadin D. Bugarčić*b  and  Rudi van Eldik*c  

* Corresponding authors

a Department of Chemical-Technological Sciences, State University of Novi Pazar, Novi Pazar, Serbia

b Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovića 12, P. O. Box 60, Kragujevac, Serbia
E-mail: bugarcic@kg.ac.rs
Fax: +381(0)34335040
Tel: +381(0)34300262

c Inorganic Chemistry, Department of Chemistry and Pharmacy, University of Erlangen-Nürnberg, Egerlandstrasse 1, Erlangen, Germany
E-mail: vaneldik@chemie.uni-erlangen.de
Fax: +49(0)91318527387
Tel: +49(0)91318527350

Abstract

The novel dinuclear Pt(II) complexes [{trans-Pt(NH3)2Cl}2(μ-pyrazine)](ClO4)2 (Pt1), [{trans-Pt(NH3)2Cl}2(μ-4,4′-bipyridyl)](ClO4)2·DMF (Pt2), and [{trans-Pt(NH3)2Cl}2(μ-1,2-bis(4-pyridyl)ethane)](ClO4)2 (Pt3), were synthesized. Acid–base titrations, and temperature and concentration dependent kinetic measurements of the reactions with biologically relevant ligands such as thiourea (Tu), glutathione (GSH) and guanosine-5′-monophosphate (5′-GMP) were studied at pH 2.5 and 7.2. The reactions were followed under pseudo-first-order conditions by stopped-flow and UV-vis spectrophotometry. 1H NMR spectroscopy was used to follow the substitution of chloride in the complex [{trans-Pt(NH3)2Cl}2(μ-4,4′-bipyridyl)](ClO4)2·DMF by guanosine-5′-monophosphate (5′-GMP) under second-order conditions. The results indicate that the bridging ligand has an influence on the reactivity of the complexes towards nucleophiles. The order of reactivity of the investigated complexes is Pt1 > Pt2 > Pt3.

Graphical abstract: Substitution behaviour of novel dinuclear Pt(ii) complexes with bio-relevant nucleophiles

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Article information

DOI
https://doi.org/10.1039/C1DT11313E
Article type
Paper
Submitted
11 Jul 2011
Accepted
11 Oct 2011
First published
08 Nov 2011

Dalton Trans., 2012,41, 876-884

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Substitution behaviour of novel dinuclear Pt(II) complexes with bio-relevant nucleophiles

T. Soldatović, S. Jovanović, Ž. D. Bugarčić and R. van Eldik, Dalton Trans., 2012, 41, 876 DOI: 10.1039/C1DT11313E

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