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Issue 12, 2012
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Hydrotalcite: recyclable, novel heterogeneous catalyst for facile, environmentally benign and high yielding multi-component synthesis and mechanistic study under solvent free conditions

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Abstract

The synthesis of the 4H-pyrimido[2,1-b][1,3]benzothiazole (1a–1h), 1,2,4-triazoloquinazolines (2a,2b), octahydroquinazolinones (3a,3b) and fused thiazolo[2,3-b]quinazolinone (4a,4b) by multicomponent reactions using aldehydes, dicarbonyl and 2-amino benzothiazole/3-amino-1,2,4-triazole/urea/thiorea has been carried out in the presence of Mg–Al–CO3 and Ca–Al–CO3 hydrotalcite as a heterogeneous catalyst. Hydrotalcites need short reaction times, are non-toxic, easy to work up and reusable under solvent free conditions, hence making this process environment friendly. A detailed mechanistic study shows that the reaction using urea proceeds through imine intermediate 6. In addition, we have isolated and characterized the key intermediate of the reaction by using hydrotalcite.

Graphical abstract: Hydrotalcite: recyclable, novel heterogeneous catalyst for facile, environmentally benign and high yielding multi-component synthesis and mechanistic study under solvent free conditions

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Publication details

The article was received on 06 Feb 2012, accepted on 16 Jul 2012 and first published on 17 Jul 2012


Article type: Paper
DOI: 10.1039/C2CY20067H
Citation: Catal. Sci. Technol., 2012,2, 2465-2475
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    Hydrotalcite: recyclable, novel heterogeneous catalyst for facile, environmentally benign and high yielding multi-component synthesis and mechanistic study under solvent free conditions

    P. K. Sahu, P. K. Sahu, R. Jain, R. Yadav and D. D. Agarwal, Catal. Sci. Technol., 2012, 2, 2465
    DOI: 10.1039/C2CY20067H

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