Stereoselective asymmetric hydrogenation of 2-benzamidomethyl-3-oxobutanoate catalyzed by Pregosin's hydrido complexes of type Ru(H)(p-cymene)(bis-phosphine)(SbF6)

P. Satyanarayana; H. Maheswaran; M. Lakshmi Kantam; H. P. S. Chawla

doi:10.1039/C2CY20335A

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Stereoselective asymmetric hydrogenation of 2-benzamidomethyl-3-oxobutanoate catalyzed by Pregosin's hydrido complexes of type Ru(H)(p-cymene)(bis-phosphine)(SbF₆)†

P. Satyanarayana,^a H. Maheswaran,*^a M. Lakshmi Kantam^a and H. P. S. Chawla^b

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* Corresponding authors

^a Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology, Hyderabad, India
E-mail: maheswaran_dr@yahoo.com
Fax: +91 40 27193510
Tel: +91 40 27191532

^b Unimark Remedies Limited, Mumbai, India

Abstract

Pregosin's complex Ru(H)(p-cymene)((R)-DTBM-Segphos)(SbF₆) has been shown to be an efficient catalyst for stereoselective asymmetric hydrogenation of 2-benzamido-methyl-3-oxobutanoate to syn-(2S,3R)-methyl-2-(benzamido-methyl)-3-hydroxybutanoate in high diastereoselectivity and enantioselectivity in ethanol.

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Article information

DOI: https://doi.org/10.1039/C2CY20335A
Article type: Paper
Submitted: 21 May 2012
Accepted: 03 Aug 2012
First published: 23 Aug 2012

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Catal. Sci. Technol., 2012,2, 2508-2511

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Stereoselective asymmetric hydrogenation of 2-benzamidomethyl-3-oxobutanoate catalyzed by Pregosin's hydrido complexes of type Ru(H)(p-cymene)(bis-phosphine)(SbF₆)

P. Satyanarayana, H. Maheswaran, M. Lakshmi Kantam and H. P. S. Chawla, Catal. Sci. Technol., 2012, 2, 2508 DOI: 10.1039/C2CY20335A

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