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Issue 8, 2012
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Asymmetric reduction of a key intermediate of eslicarbazepine acetate using whole cell biotransformation in a biphasic medium

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Abstract

A whole-cell mediated asymmetric reduction of oxcarbazepine 1 to S-licarbazepine 2, a key intermediate in the synthesis of Eslicarbazepine acetate, was achieved using the yeast strain Pichia methanolica 103660. The reduction was carried out in a biphasic system consisting of (1 : 1) de-ionized water and hexane. This organism catalyzed the reaction to yield the S-enantiomer 2 with excellent conversion (>98%) and enantiomeric excess (ee > 98%) within 24 h of incubation.

Graphical abstract: Asymmetric reduction of a key intermediate of eslicarbazepine acetate using whole cell biotransformation in a biphasic medium

  • This article is part of the themed collection: Biocatalysis
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Article information


Submitted
21 Dec 2011
Accepted
09 Feb 2012
First published
10 Feb 2012

Catal. Sci. Technol., 2012,2, 1602-1605
Article type
Paper

Asymmetric reduction of a key intermediate of eslicarbazepine acetate using whole cell biotransformation in a biphasic medium

M. Singh, S. Singh, S. Deshaboina, H. Krishnen, R. Lloyd, K. Holt-Tiffin, A. Bhattacharya and R. Bandichhor, Catal. Sci. Technol., 2012, 2, 1602
DOI: 10.1039/C2CY00537A

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