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Issue 1, 2012
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Efficient organocatalysts derived from simple chiral acyclic amino acids in asymmetric catalysis

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Abstract

Chiral amino acids have played a key role in the development of organocatalysis from a biomimetic concept to an independent methodology, together with metal catalysis and enzyme catalysis, comprising the three major catalytic methodologies in modern organic synthesis. As an excellent pool for the design of organocatalysts, chiral amino acids have two obvious advantages: ready availability with usually affordable costs and modular structures allowing facile tuning of the catalytic efficiency. Recently, bifunctional/multifunctional primary–secondary amines, tertiary aminethioureas, aminophosphines easily prepared from simple acyclic amino acids have been developed as efficient organocatalysts for various asymmetric reactions leading to a variety of useful chiral compounds. In this perspective, we present a personal overview of some of these recent advances in this field based on our own research experience.

Graphical abstract: Efficient organocatalysts derived from simple chiral acyclic amino acids in asymmetric catalysis

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Publication details

The article was received on 30 Aug 2011, accepted on 17 Oct 2011 and first published on 10 Nov 2011


Article type: Perspective
DOI: 10.1039/C1CY00347J
Citation: Catal. Sci. Technol., 2012,2, 29-41

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    Efficient organocatalysts derived from simple chiral acyclic amino acids in asymmetric catalysis

    Z. Chai and G. Zhao, Catal. Sci. Technol., 2012, 2, 29
    DOI: 10.1039/C1CY00347J

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