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Issue 10, 2012
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A walk around the A3-coupling

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In recent years, the transition-metal catalyzed three-component coupling of an aldehyde, an alkyne and an amine, commonly called A3-coupling, has been established as a convenient and general approach towards propargylamines. Furthermore, the A3-coupling has found a broad application as a key step in the construction of various nitrogen-containing heterocycles, biologically active compounds and natural products. Several interesting modifications of the A3-coupling as well as different tandem reactions involving A3-coupling have been developed. This tutorial review aims to highlight the current achievements in the field of A3-couplings and related transformations.

Graphical abstract: A walk around the A3-coupling

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Article information

23 Dec 2011
First published
15 Mar 2012

Chem. Soc. Rev., 2012,41, 3790-3807
Article type
Tutorial Review

A walk around the A3-coupling

V. A. Peshkov, O. P. Pereshivko and E. V. Van der Eycken, Chem. Soc. Rev., 2012, 41, 3790
DOI: 10.1039/C2CS15356D

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