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Issue 6, 2012
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Transfer hydrogenation with Hantzsch esters and related organic hydride donors

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Abstract

In recent years, Hantzsch esters and their related organic hydride donors have been widely utilized in biomimetic approaches of asymmetric transfer hydrogenation (ATH) reactions. Various compounds containing C[double bond, length as m-dash]C, C[double bond, length as m-dash]N and C[double bond, length as m-dash]O unsaturated functionalities could be reduced in the presence of organocatalysts or transition metal complexes, affording versatile chiral building blocks in high yields and excellent enantioselectivities under mild conditions. In this critical review, recent advances in this area are summarized and classified according to unsaturated functional groups being reduced and catalytic systems employed (91 references).

Graphical abstract: Transfer hydrogenation with Hantzsch esters and related organic hydride donors

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Publication details

The article was received on 27 Sep 2011 and first published on 27 Jan 2012


Article type: Critical Review
DOI: 10.1039/C1CS15268H
Citation: Chem. Soc. Rev., 2012,41, 2498-2518
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    Transfer hydrogenation with Hantzsch esters and related organic hydride donors

    C. Zheng and S. You, Chem. Soc. Rev., 2012, 41, 2498
    DOI: 10.1039/C1CS15268H

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