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Issue 21, 2012
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Privileged scaffolds in synthesis: 2,5-piperazinediones as templates for the preparation of structurally diverse heterocycles

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Abstract

2,5-Piperazinediones (2,5-diketopiperazines, DKPs) can be viewed as privileged building blocks for the synthesis of heterocyclic systems. This tutorial review aims at underscoring the large number and structural variety of nitrogen heterocycles that are available by suitable manipulation of DKP starting materials, including many bioactive compounds and natural products.

Graphical abstract: Privileged scaffolds in synthesis: 2,5-piperazinediones as templates for the preparation of structurally diverse heterocycles

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Publication details

The article was received on 25 Apr 2012 and first published on 25 Jul 2012


Article type: Tutorial Review
DOI: 10.1039/C2CS35158G
Chem. Soc. Rev., 2012,41, 6902-6915

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    Privileged scaffolds in synthesis: 2,5-piperazinediones as templates for the preparation of structurally diverse heterocycles

    J. F. González, I. Ortín, E. de la Cuesta and J. C. Menéndez, Chem. Soc. Rev., 2012, 41, 6902
    DOI: 10.1039/C2CS35158G

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