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Issue 8, 2012
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Asymmetric homogeneous hydrogenations at scale

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Abstract

Asymmetric hydrogenations are increasingly being used to introduce stereogenic centres into products used in the life sciences industries. There are a number of potential pitfalls when moving from a laboratory reaction to a manufacturing process, not least of which is safety. Time-to-market pressure leads to short development times, which in the past could be a large barrier for the implementation of catalytic steps; now there are new ways to minimise this problem. The potential problems associated with impurities and other methods that can shut down the hydrogenation reactions are highlighted in this critical review (353 references).

Graphical abstract: Asymmetric homogeneous hydrogenations at scale

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Publication details

The article was received on 17 Nov 2011 and first published on 08 Feb 2012


Article type: Critical Review
DOI: 10.1039/C2CS15312B
Chem. Soc. Rev., 2012,41, 3340-3380

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    Asymmetric homogeneous hydrogenations at scale

    D. J. Ager, A. H. M. de Vries and J. G. de Vries, Chem. Soc. Rev., 2012, 41, 3340
    DOI: 10.1039/C2CS15312B

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