Jump to main content
Jump to site search

Issue 1, 2012
Previous Article Next Article

Designs for life: protocell models in the laboratory

Author affiliations

Abstract

Compartmentalization of primitive biochemical reactions within membrane-bound water micro-droplets is considered an essential step in the origin of life. In the absence of complex biochemical machinery, the hypothetical precursors to the first biological cells (protocells) would be dependent on the self-organization of their components and physicochemical conditions of the environment to attain a basic level of autonomy and evolutionary viability. Many researchers consider the self-organization of lipid and fatty acid molecules into bilayer vesicles as a simple form of membrane-based compartmentalization that can be developed for the experimental design and construction of plausible protocell models. In this tutorial review, we highlight some of the recent advances and issues concerning the construction of simple cell-like systems in the laboratory. Overcoming many of the current scientific challenges should lead to new types of chemical bio-reactors and artificial cell-like entities, and bring new insights concerning the possible pathways responsible for the origin of life.

Graphical abstract: Designs for life: protocell models in the laboratory

Back to tab navigation

Publication details

The article was received on 09 Aug 2011 and first published on 27 Sep 2011


Article type: Tutorial Review
DOI: 10.1039/C1CS15211D
Citation: Chem. Soc. Rev., 2012,41, 79-85
  •   Request permissions

    Designs for life: protocell models in the laboratory

    A. J. Dzieciol and S. Mann, Chem. Soc. Rev., 2012, 41, 79
    DOI: 10.1039/C1CS15211D

Search articles by author

Spotlight

Advertisements