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Issue 44, 2012
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Volumetric stability of lipid bilayers

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In agreement with recent reports, a commercial densimeter has yielded a gradual decrease in lipid molecular volume of DPPC multilamellar vesicle dispersions in the gel phase upon repeated thermal cycling between 10 °C and 50 °C. The considerable size of this decrease would have significant implications for the physical chemistry of biomembranes. In contrast, neutral buoyancy measurements performed with similar thermal cycling indicate no gradual change in lipid volume in the gel phase at 20 °C. Remixing the lipid in the densimeter shows that the apparent volume decrease is an artifact. We conclude that gel phase DPPC bilayers exist in a volumetrically stable phase.

Graphical abstract: Volumetric stability of lipid bilayers

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Publication details

The article was received on 27 Jul 2012, accepted on 03 Oct 2012 and first published on 03 Oct 2012

Article type: Paper
DOI: 10.1039/C2CP42595E
Phys. Chem. Chem. Phys., 2012,14, 15452-15457

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    Volumetric stability of lipid bilayers

    K. M. Hallinen, S. Tristram-Nagle and J. F. Nagle, Phys. Chem. Chem. Phys., 2012, 14, 15452
    DOI: 10.1039/C2CP42595E

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