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Issue 23, 2012
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Polymorphism in an API ionic liquid: ethambutol dibenzoate trimorphs

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Abstract

Three polymorphs of the dibenzoate salt of the anti-tubercular drug ethambutol (EDB) were crystallized as ionic liquids (m.p. < 100 °C) and characterized by diffraction (PXRD), thermal (DSC) and spectroscopy (IR, Raman, ss-NMR) techniques. Their stability relationships were established by DSC and VT-PXRD: EDB form 1 is the most stable, followed by form 3, and form 2 is the least stable at room temperature (25 °C); form 3 is the most stable, then form 1, and form 2 is the least stable at high temperature (90 °C).

Graphical abstract: Polymorphism in an API ionic liquid: ethambutol dibenzoate trimorphs

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Article information


Submitted
28 May 2012
Accepted
12 Jul 2012
First published
12 Jul 2012

CrystEngComm, 2012,14, 7840-7843
Article type
Communication

Polymorphism in an API ionic liquid: ethambutol dibenzoate trimorphs

S. Cherukuvada and A. Nangia, CrystEngComm, 2012, 14, 7840
DOI: 10.1039/C2CE25842K

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