Jump to main content
Jump to site search

Issue 19, 2012
Previous Article Next Article

Examining the robustness of a theophylline cocrystal during grinding with additives

Author affiliations

Abstract

The robustness of theophylline-p-hydroxybenzoic acid cocrystal (TP·pHBA) while grinding with additives in the solid state was evaluated through a series of solvent-drop grinding experiments with coformers containing various functional groups. Powder X-ray diffraction was used to qualitatively analyse the powders after grinding and identify the species present. The TP·pHBA cocrystal was found to be robust in the presence of benzoic acid (BA), p-nitrobenzoic acid (pNBA), p-(N,N-dimethylamino)benzoic acid (dMABA), m-hydroxybenzoic acid (mHBA), p-nitrophenol (pNP), hydroquinone (HDQ) and benzamide (BZA), but it disintegrates in the presence of salicylic acid (SA), 3,5-dinitrobenzoic acid (dNBA), acetamide (ACA) and melamine (MLM).

Graphical abstract: Examining the robustness of a theophylline cocrystal during grinding with additives

Back to tab navigation

Supplementary files

Article information


Submitted
04 Apr 2012
Accepted
23 Apr 2012
First published
25 Apr 2012

CrystEngComm, 2012,14, 6163-6169
Article type
Paper

Examining the robustness of a theophylline cocrystal during grinding with additives

H. Abourahma, J. M. Urban, N. Morozowich and B. Chan, CrystEngComm, 2012, 14, 6163
DOI: 10.1039/C2CE25495F

Social activity

Search articles by author

Spotlight

Advertisements