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Issue 7, 2012
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Toward supramolecular architectures of the anti-HIV druglamivudine: understanding the effect of the inclusion of water in a hydrochloride form

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Abstract

Two salts of the anti-HIV drug lamivudine, namely, lamivudine hydrochloride and lamivudine hydrochloride monohydrate, were prepared for the first time. Structural relationships and the role of water in crystal assembly and lamivudine conformation were established and allowed for a rational approach to understand how solid state properties could be changed by engineering new salts of the drug.

Graphical abstract: Toward supramolecular architectures of the anti-HIV drug lamivudine: understanding the effect of the inclusion of water in a hydrochloride form

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Article information


Submitted
30 Sep 2011
Accepted
08 Dec 2011
First published
05 Jan 2012

CrystEngComm, 2012,14, 2373-2376
Article type
Communication

Toward supramolecular architectures of the anti-HIV drug lamivudine: understanding the effect of the inclusion of water in a hydrochloride form

J. Ellena, N. Paparidis and F. T. Martins, CrystEngComm, 2012, 14, 2373
DOI: 10.1039/C2CE06303D

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