An amphiphilic calix[4]arene derivative bearing four guanidino moieties at the upper rim and four dodecyl chains at the lower rim was shown to form stable solid lipid nanoparticles (SLNs) in water. The study of the interactions of these cationic SLNs with DNA revealed a sequence-dependent groove binding mechanism.
V. Rullaud, M. Siragusa, A. Cumbo, D. Gygax and P. Shahgaldian, Chem. Commun., 2012, 48, 12186 DOI: 10.1039/C2CC36859E
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