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Issue 85, 2012
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Catalysis-based enantioselective total synthesis of myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F

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Abstract

A common strategy for the stereoselective and protecting group-free total synthesis of the myxobacterial antibiotics myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F is described featuring an asymmetric organocatalytic transfer hydrogenation, a palladium-catalyzed Stille coupling and a cross-metathesis as the key steps.

Graphical abstract: Catalysis-based enantioselective total synthesis of myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F

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Article information


Submitted
07 Aug 2012
Accepted
05 Sep 2012
First published
06 Sep 2012

Chem. Commun., 2012,48, 10508-10510
Article type
Communication

Catalysis-based enantioselective total synthesis of myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F

A. Colon, T. J. Hoffman, J. Gebauer, J. Dash, J. H. Rigby, S. Arseniyadis and J. Cossy, Chem. Commun., 2012, 48, 10508
DOI: 10.1039/C2CC35721F

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