Jump to main content
Jump to site search

Issue 80, 2012
Previous Article Next Article

Enantioselective organocatalytic domino synthesis of tetrahydropyridin-2-ols

Author affiliations

Abstract

The asymmetric synthesis of tetrahydropyridin-2-ols from enals and enaminones is described. The organocatalytic domino reaction involves a Michael addition–hemiaminalization sequence using the Jørgensen–Hayashi catalyst. Dehydration or oxidation leads to the corresponding 1,4-dihydro-pyridines or 3,4-dihydropyridin-2-ones in a one-pot fashion.

Graphical abstract: Enantioselective organocatalytic domino synthesis of tetrahydropyridin-2-ols

Back to tab navigation

Supplementary files

Article information


Submitted
03 Aug 2012
Accepted
22 Aug 2012
First published
22 Aug 2012

Chem. Commun., 2012,48, 10049-10051
Article type
Communication

Enantioselective organocatalytic domino synthesis of tetrahydropyridin-2-ols

J. Wan, C. C. J. Loh, F. Pan and D. Enders, Chem. Commun., 2012, 48, 10049
DOI: 10.1039/C2CC35644A

Social activity

Search articles by author

Spotlight

Advertisements