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Issue 77, 2012
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Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window

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Abstract

Incorporation of biquinoline ligands into Ru(II) polypyridyl complexes produces light-activated systems that eject a ligand and photobind DNA after irradiation with visible and near-IR light. Structural analysis shows that distortion facilitates the photochemistry, and gel shift and cytotoxicity studies prove the compounds act as anti-cancer photodynamic therapy (PDT) agents in the tissue penetrant region.

Graphical abstract: Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window

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The article was received on 09 May 2012, accepted on 12 Jul 2012 and first published on 24 Jul 2012


Article type: Communication
DOI: 10.1039/C2CC33359G
Chem. Commun., 2012,48, 9649-9651

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    Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window

    E. Wachter, D. K. Heidary, B. S. Howerton, S. Parkin and E. C. Glazer, Chem. Commun., 2012, 48, 9649
    DOI: 10.1039/C2CC33359G

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