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Issue 56, 2012
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Fucose-specific conjugation of hydrazide derivatives to a vascular-targeting monoclonal antibody in IgG format

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Abstract

We describe a method that enables specific and efficient conjugation of hydrazide-moieties to an IgG targeting the tumor neovasculature. The resulting chemically defined, homogeneous hydrazone-linked IgG conjugates remain immunoreactive and have a half-life of approximately 18 hours at physiological pH and temperature suitable for localized delivery of toxic drugs.

Graphical abstract: Fucose-specific conjugation of hydrazide derivatives to a vascular-targeting monoclonal antibody in IgG format

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Article information


Submitted
03 Apr 2012
Accepted
23 May 2012
First published
23 May 2012

Chem. Commun., 2012,48, 7100-7102
Article type
Communication

Fucose-specific conjugation of hydrazide derivatives to a vascular-targeting monoclonal antibody in IgG format

K. Zuberbühler, G. Casi, G. J. L. Bernardes and D. Neri, Chem. Commun., 2012, 48, 7100
DOI: 10.1039/C2CC32412A

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