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Issue 59, 2012
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Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride

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Abstract

Histamine is a biogenic amine with fundamental roles in circulatory and immune systems. We report a fluorescent small molecule (Histamine Blue) for imaging intracellular histamine in live basophils and macrophages. Histamine Blue is a fluorescent mesoionic acid fluoride that turns on upon reaction with histamine. The selective response of Histamine Blue enabled the visualization of intracellular histamine under different physiological conditions.

Graphical abstract: Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride

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Publication details

The article was received on 30 Mar 2012, accepted on 29 May 2012 and first published on 30 May 2012


Article type: Communication
DOI: 10.1039/C2CC32292G
Chem. Commun., 2012,48, 7401-7403

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    Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride

    N. Kielland, M. Vendrell, R. Lavilla and Y. Chang, Chem. Commun., 2012, 48, 7401
    DOI: 10.1039/C2CC32292G

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