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Issue 71, 2012
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Imaging beyond the proteome

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Imaging technologies developed in the early 20th century achieved contrast solely by relying on macroscopic and morphological differences between the tissues of interest and the surrounding tissues. Since then, there has been a movement toward imaging at the cellular and molecular level in order to visualize biological processes. This rapidly growing field is known as molecular imaging. In the last decade, many methodologies for imaging proteins have emerged. However, most of these approaches cannot be extended to imaging beyond the proteome. Here, we highlight some of the recently developed technologies that enable imaging of non-proteinaceous molecules in the cell: lipids, signalling molecules, inorganic ions, glycans, nucleic acids, small-molecule metabolites, and protein post-translational modifications such as phosphorylation and methylation.

Graphical abstract: Imaging beyond the proteome

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Publication details

The article was received on 13 Mar 2012, accepted on 14 Jun 2012 and first published on 17 Jul 2012

Article type: Feature Article
DOI: 10.1039/C2CC31845H
Chem. Commun., 2012,48, 8864-8879

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    Imaging beyond the proteome

    P. V. Chang and C. R. Bertozzi, Chem. Commun., 2012, 48, 8864
    DOI: 10.1039/C2CC31845H

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