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Issue 45, 2012
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In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

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Abstract

New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strain expressing the bbBeas gene.

Graphical abstract: In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

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Publication details

The article was received on 06 Mar 2012, accepted on 17 Apr 2012 and first published on 01 May 2012


Article type: Communication
DOI: 10.1039/C2CC31669B
Citation: Chem. Commun., 2012,48, 5674-5676
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    In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

    D. Matthes, L. Richter, J. Müller, A. Denisiuk, S. C. Feifel, Y. Xu, P. Espinosa-Artiles, R. D. Süssmuth and I. Molnár, Chem. Commun., 2012, 48, 5674
    DOI: 10.1039/C2CC31669B

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