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Issue 46, 2012
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Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy

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Abstract

Chelate stabilization of a titanium(IV)–salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.

Graphical abstract: Synthesis and X-ray structure analysis of a heptacoordinate titanium(iv)-bis-chelate with enhanced in vivo antitumor efficacy

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Publication details

The article was received on 04 Mar 2012, accepted on 16 Apr 2012 and first published on 17 Apr 2012


Article type: Communication
DOI: 10.1039/C2CC31624B
Citation: Chem. Commun., 2012,48, 5790-5792

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    Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy

    T. A. Immel, M. Grützke, A. Späte, U. Groth, P. Öhlschläger and T. Huhn, Chem. Commun., 2012, 48, 5790
    DOI: 10.1039/C2CC31624B

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