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Issue 50, 2012
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Enantioselective Friedel–Crafts reactions in water catalyzed by a human telomeric G-quadruplex DNA metalloenzyme

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Abstract

A human telomeric G-quadruplex (G4DNA) metalloenzyme, assembled with G4DNA and Cu2+ ions, can catalyze the enantioselective Friedel–Crafts (F–C) reaction in water with good enantioselectivity (up to 75% ee). Furthermore, we found that the absolute configuration and the enantioselectivity of the product largely depend on the conformation and the sequence of G4DNA.

Graphical abstract: Enantioselective Friedel–Crafts reactions in water catalyzed by a human telomeric G-quadruplex DNA metalloenzyme

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Supplementary files

Article information


Submitted
22 Feb 2012
Accepted
02 May 2012
First published
03 May 2012

Chem. Commun., 2012,48, 6232-6234
Article type
Communication

Enantioselective Friedel–Crafts reactions in water catalyzed by a human telomeric G-quadruplex DNA metalloenzyme

C. Wang, Y. Li, G. Jia, Y. Liu, S. Lu and C. Li, Chem. Commun., 2012, 48, 6232
DOI: 10.1039/C2CC31320K

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