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Issue 34, 2012
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Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides

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Abstract

The direct synthesis of dithiophenol maleimide functional polymers by living radical polymerisation is described without the need for protecting group chemistry. The synthesised polymers have been successfully employed as disulfide bridging agents for salmon calcitonin when used in equimolar quantities, negating the requirement for complex purification strategies, traditionally associated with peptide bioconjugation.

Graphical abstract: Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides

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Publication details

The article was received on 12 Jan 2012, accepted on 28 Feb 2012 and first published on 29 Feb 2012


Article type: Communication
DOI: 10.1039/C2CC30259D
Citation: Chem. Commun., 2012,48, 4064-4066
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    Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides

    M. W. Jones, R. A. Strickland, F. F. Schumacher, S. Caddick, James. R. Baker, M. I. Gibson and D. M. Haddleton, Chem. Commun., 2012, 48, 4064
    DOI: 10.1039/C2CC30259D

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