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Issue 29, 2012
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Convergent integration of two self-labor domino sequences: a novel method for the synthesis of oxazole derivatives from methyl ketones and benzoins

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Abstract

A highly efficient method for the synthesis of oxazole derivatives from methyl ketones, benzoins and ammonium acetate has been established via a novel strategy—convergent integration of two self-labor domino sequences. Owing to the simple and readily available starting materials, mild reaction conditions, facile operation, and the high bioactivity of oxazole derivatives, this reaction promises diverse applications in medical chemistry. Additionally, this reaction could provide an efficient example for self-labor synthesis strategy of organic compounds.

Graphical abstract: Convergent integration of two self-labor domino sequences: a novel method for the synthesis of oxazole derivatives from methyl ketones and benzoins

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Article information


Submitted
26 Dec 2011
Accepted
07 Jan 2012
First published
10 Jan 2012

Chem. Commun., 2012,48, 3485-3487
Article type
Communication

Convergent integration of two self-labor domino sequences: a novel method for the synthesis of oxazole derivatives from methyl ketones and benzoins

W. Xue, Q. Li, Y. Zhu, J. Wang and A. Wu, Chem. Commun., 2012, 48, 3485
DOI: 10.1039/C2CC18077D

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